This is monumentally good. I have watched it three times for the sake of thorough notes and I'm grateful I found it.
The focus in biology has changed from mechanics to informatics. Cells are sensitive and communicative information-processing entities.
Cell generated hereditary innovation is the source of new features in evolution.
Genome change is a cell-regulated process, not a series of accidents. (Genome as RW, not ROM, memory system.)
The DNA record tells us that major steps in genome evolution have involved rapid genome-wide changes.
We know of rapid molecular processes that allow us to think scientifically about complex evolutionary events - particularly about the rapid evolution of genomic circuits and multi-component adaptations.